|
KMID : 1140120080130030189
|
|
Cancer Prevention Research
2008 Volume.13 No. 3 p.189 ~ p.196
|
|
|
Changes of Interferon-γ and IL-4, and Cell Vitality by Infection of Toxoplasma gondii in Rat Glioma C6 Cells
|
|
Lee Kwang-Yeon
Choi Won-Hyung
Yoo Jae-Young
Jiang Meihua
Chu Jong-Phil
Park Jin-Hee
Park Yoo-Sin
Kang Ju-Seop
Nam Ho-Woo
Lee Yun-Sik
|
|
|
Abstract
|
|
|
|
Toxoplasma gondii, a parasite that infects domestic animals and human, induces toxoplasmosis in the human brain. Despite the importance in the biological proliferation mechanism of T. gondii in the human brain, there are only handful of reports related to the parasite’s intrusion process to enter the host and a survival rate of the host brain cell. This research is a pivotal one that studies apoptosis and inhibition of host cell growth in C6 glioma cells infected with the parasites. As a result of T. gondii treatment, activation of caspase-3, IL-4 depression, INF-γ increasement and change of nuclear translocation of STAT signal resulted in mice macrophages and C6 cells. Examining the T. gondii-induced apoptosis of rat glioma C6 cells can aid in developing a preventative treatment for cancer, especially in the elderly through a knowledge of signal suppression, survival rate of the host cell and antigen excretion in a late-onset cancer immunity. (Cancer Prev Res 13, 189-196, 2008)
|
|
|
KEYWORD
|
|
|
Toxoplasma gondii, Rat glioma C6 cells, Interferon-γ, IL-4, Apoptosis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|